The focus of the seminar series is to call for experts related to academia and research in the areas related to biomechanics, variability, motor disorders, physical therapy, and related studies.

Presentation Title: Vascular Growth and Remodeling in Health and Disease

Presentation Abstract:

Blood vessels continuously grow and remodel in health and disease. Mechanics is a critical stimulus in this process. In this talk, with vein grafts and large pulmonary arteries as examples, I will highlight how vascular mechanics affects and is affected by remodeling. I will present mechanics-based, biology-informed computational multiscale models that enabled better insights into vascular adaptation and aided translation of novel solutions to prevent graft failure. I will also present data on murine large pulmonary artery remodeling in development, ageing and disease.

About the speaker:

Abhay Ramachandra is a mechanical engineer by training and received his PhD in Engineering Sciences from the Department of Mechanical and Aerospace Engineering at the University of California San Diego, CA. He subsequently pursued a postdoc in experimental vascular mechanics and mechanobiology in the Department of Biomedical Engineering at Yale University, CT. He is currently an Assistant Professor in the Department of Mechanical Engineering at Iowa State University. Abhay’s research interest is in cardiovascular mechanics and adaptation. He is trained in both computational and experimental biomechanics and has applied his training to multiple problems in vascular adaptation including vein graft failure in coronary artery bypass graft surgery, tissue engineered vascular grafts, systemic hypertension, aortic dissection and various pulmonary pathologies. Abhay is also passionate about translational research.